Isopropyl Myristate

Catalog	ACM110270
CAS	110-27-0
Structure
Description	Ester of isopropyl alcohol and myristic acid (vegetable-derived). Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants. Thanks to its low viscosity and density, it has a high spreadability. Specific gravity 0.85 (at 20°C).
Synonyms	1-Methylethyl tetradecanoate
IUPAC Name	Propan-2-yl tetradecanoate
Molecular Weight	270.5
Molecular Formula	C17H34O2
Canonical SMILES	CCCCCCCCCCCCCC(=O)OC(C)C
InChI	InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3
InChI Key	AXISYYRBXTVTFY-UHFFFAOYSA-N
Boiling Point	193 °C
Melting Point	3 °C
Flash Point	>230 °F
Purity	95%+
Density	0.85 g/mL at 25 °C(lit.)
Solubility	Water-insoluble, but soluble with silicones, and hydrocarbons
Appearance	Colorless oil-like liquid, odorless
Application	Creams, lotions, hand creams, shampoo, shower gels, makeup removers, powders and foundations.
Storage	Store in a closed container at a dry place at room temperature
Exact Mass	270.255880323
Monoisotopic Mass	270.255880323
Odor	Practically odorless
Physical State	Liquid
Refractive Index	n20/D 1.434(lit.)
Storage Conditions	2-8 °C
Topological Polar Surface Area	26.3 Ų

Case Study

Reactive Distillation Design for Production of Isopropyl Myristate

Pushkala, S. Purna, et al. Cleaner Chemical Engineering, 2023, 5, 100090.

Isopropyl myristate (IPM) can be produced by esterification of myristic acid and isopropyl alcohol in a reactive distillation column. In order to realize the IPM production process with high purity and high conversion rate, the reactive distillation tower and IMC-PID controller were designed using the IMC-PID-Laurent tuning method.
Production process of isopropyl myristate
· The feeds [isopropyl alcohol (IPA) and myristic acid (MA)] are fed into the reaction tower, and an esterification reaction occurs between IPA and MA in the liquid phase.
· The production design of IPM is based on azeotropic reaction distillation of entrainer. In such processes, an entrainer (cyclohexane) is added to remove water, preventing the formation of an azeotrope and thereby shifting the equilibrium forward.
· The optimal operating conditions for a reactive distillation column used to produce IPM include column pressure of 1 atm, universal gas constant of 8.3144 L bar/mol K, chemical equilibrium constant of 2, reflux of 1.99 Cal/K.mol, reboiler duty of 0.99 kJ/s, fresh liquid/vapor feed of flow rate of 12.6 mole/s, and distillate/bottom flow rate of 12.6mole fraction, etc.

Formation of Surfactant Mixed Microemulsion Using Isopropyl Myristate as Oil

Soumik Bardhan, et al. Journal of colloid and interface science, 2014, 430, 129-139.

This work reports a mixed surfactant-derived microemulsion system based on isopropyl myristate (IPM) polar lipophilic oil. In this system, a mixed surfactant microenvironment consists of cationic (cetyltrimethylammonium bromide, CTAB) and nonionic (Brij-35) stabilized in 1-pentanol (Pn) and IPM.
Construction of pseudo ternary phase diagram of microemulsions
· A pseudo-ternary phase diagram was created to determine the concentration range at which microemulsions are formed by the components (oil/water/surfactant and/or cosurfactant). This diagram was constructed using the titrimetric method at room temperature.
· A mixture of oil (IPM) and surfactant (CTAB and Brij-35) was prepared with varying weight percentages, while maintaining a 1:2 ratio of surfactant to cosurfactant (Pn). The mixture was then slowly titrated with water under gentle magnetic stirring and sonicated for 10 minutes.
· Samples were classified as microemulsions if they appeared as clear, transparent, and translucent liquids, and were left overnight to ensure no phase separation occurred. After equilibration, the systems were visually assessed, with the accuracy of the phase boundaries being within 4 wt%.