L-Aspartic acid

Catalog	ACM56848
CAS	56-84-8
Structure
Description	Aspartic acid (abbreviated as Asp or D; encoded by the codons [GAU and GAC]), also known as aspartate, is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+ 3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain CH2COOH. Under physiological conditions in proteins the sidechain usually occurs as the negatively charged aspartate form, −COO−. It is semi-essential in humans, meaning the body can synthesize it from oxaloacetate.In proteins aspartate sidechains are often hydrogen bonded, often as asx turns or asx motifs, which often occur at the N-termini of alpha helices.Asp’s L-isomer is one of the 23 proteinogenic amino acids, i.e., the building blocks of proteins. Asp (and glutamic acid) is classified as acidic, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment (as with all amino acids), and could be as high as 14. Asp is pervasive in biosynthesis.L-aspartic acid is one of the two main ingredients of the artificial sweetener aspartame, along with L-phenylalanine.
Synonyms	(S)-Butanedioicaci
IUPAC Name	(2S)-2-Aminobutanedioic acid
Molecular Weight	133.1
Molecular Formula	C4H7NO4
Canonical SMILES	C(C(C(=O)O)N)C(=O)O
InChI	InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI Key	CKLJMWTZIZZHCS-REOHCLBHSA-N
Boiling Point	245.59 °C
Melting Point	>300 °C(lit.)
Flash Point	113.5 °C
Purity	98%
Density	1.66 g/cm³
Solubility	Slightly soluble in water, insoluble in ether
Appearance	White powder
Storage	Store below +30 °C
Exact Mass	133.03750770
Isomeric SMILES	C([C@@H](C(=O)O)N)C(=O)O
Monoisotopic Mass	133.03750770
Physical State	Powder
Refractive Index	1.66
Storage Conditions	Below +30 °C
Topological Polar Surface Area	101 Ų